Town came away from Elland Road with a well-earned point in the first goalless draw since the start of September.
Tamas Priskin twice went close for Blues in the first-half, dragging his first effort wide in just 14 seconds after he had got on the end of a long ball.
Lee Martin was denied by Kasper Schmeichel while Max Gradel brought saves from Marton Fulop in a game that always threatened a goal.
Town made three changes from the side that went down to Reading in midweek, Jimmy Bullard returning to the line-up in place of the suspended David Norris. Priskin was handed the responsibility of leading the attack, while Kieron Dyer came in for his first appearance since returning to the Club on loan from West Ham.
Town could have been ahead inside the first minute, Priskin bursting clear but dragging his shot wide of the far post. Dyer was also immediately in the action, spinning inside the Leeds' box, his cross cleared by Andy O'Brien.
Billy Paynter picked up an early yellow card after catching Gareth McAuley with a stray arm, the Town defender needing treatment.
Priskin carved out a chance for himself on 15 minutes, with a chest control and then volley at Kasper Schmeichel.
Max Gradel carried the main threat for the home side in the first-half, the winger forcing Marton Fulop into a flying save.
O'Brien linked up well with Eric Lichaj down the right to set up Gradel at the far post but his shot was deflected wide while at the other end Priskin went close with a right foot curler.
Paynter couldn't convert George McCartney's cross at the nearpost, Schmeichel then in the right place to deny Lee Martin after he got clear.
The Leeds' 'keeper had to be alert seconds later to tip over McAuley's header, O'Brien then harshly booked for a foul on Priskin.
Carlos Edwards' instant cross looked destined for Priskin until Schmeichel intervened as Paul Jewell's side held their own.
Gradel had a shot deflected wide, with the last action of the half seeing referee Darren Deadman wave away penalty appeals after O'Brien's shot had been blocked.
Jonathan Howson volleyed wide from Robert Snodgrass' cross as Leeds started the second-half brightly, Snodgrass then sending a left foot effort inches past the far post.
Town responded, Martin dragging his side wide, while at the other end Fulop held firm from Paynter's strike.
McAuley added to the bookings on the hour after catching Paynter, O'Brien thumping a right foot 20 yarder wide seconds later.
Town made a first change midway through the second-half, with Luciano Civelli on for Martin.
Damien Delaney's positioning curtailed the danger from Lichaj's cross, O'Brien doing the same at the other end after Priskin had got around the back.
Town made a second change with Dyer replaced by Andy Drury for the last 20 minutes, Leeds also shuffling their pack with Howson making way for Barry Bannan and crowd favourite Luciano Becchio on for Paynter.
Jason Scotland completed the flurry of changes, the Trinidad international given the last 10 minutes for Priskin.
Schmeichel held firm from Wickham's cross, while his counterpart Fulop did the same at the other end to keep out Snodgrass' delivery.
Damien Delaney did brilliantly to divert the ball behind from Lichaj's cross three yards out as Leeds pressed for a late winner while at the other end Wickham was denied by McCartney's block.
The teenager became the second Blue to be booked but Town held on for the point and ended the game as much on the front foot as the Play-Off chasing hosts.
Leeds: Schmeichel, Lichaj, O'Brien, Bromby, McCartney, Gradel, Johnson, Howson (Bannan 74), Kilkenny, Paynter (Becchio 74), Snodgrass. Subs not used: Higgs, Bruce, Naylor, Watt, Somma. Booked: Paynter, O'Brien.
Town: Fulop, Edwards, McAuley, Delaney, O'Dea, Martin (Civelli 67), Bullard, Dyer (Drury 73), Leadbitter, Wickham, Priskin (Scotland 80). Subs not used: Lee-Barrett, Peters, Hyam, Smith. Booked: McAuley, Wickham.