First away trip of 2021/22 ends in a loss
A late penalty from Lucas Akins condemned Town to a narrow defeat at Burton.
An own goal from Tom O'Connor had cancelled out Joe Powell's opener, with Town seeing a penalty of their own saved and hitting the woodwork before Akins' decisive spot kick.
Paul Cook made three changes from the side that opened the season against Morecambe a week earlier.
Janoi Donacien, Louie Barry and Armando Dobra replaced Toto Nsiala, Conor Chaplin and Wes Burns.
Kyle Edwards, who joined the Club on Monday, was named on the bench.
The first chance of the game went the way of Town as Joe Pigott won an aerial battle and saw a header saved after Matt Penney had hooked Kane Vincent-Young's initial cross back into the box.
Lee Evans then headed a corner from Scott Fraser back across goal before Luke Woolfenden's well-struck volley was blocked by a Brewers defender.
Woolfenden was in the right place to block Powell's left-footed shot shortly after, Vincent-Young throwing his body in the way to block the Burton number eight's rebound attempt.
Two goals inside four first-half minutes saw the game spark into life. First, Powell slotted under Vaclav Hladky to open the scoring for Burton after 19 minutes.
Town came up with the perfect response three minutes later, though, as Evans' whipped free-kick into the box caused problems and O'Connor, under pressure from Pigott, headed past his own goalkeeper at the near post.
John Brayford volleyed wide of the mark at the back post as the sides went in level at the break.
Town nearly forced a second Burton own goal of the match 10 minutes after the break as Conor Shaughnessy sliced over the top of his own net from Rekeem Harper's drilled ball across the box.
The Blues had a golden chance to move in front a minute later after O'Connor bundled Barry over in the box. Fraser stepped up but saw his penalty saved by Ben Garratt.
A dangerous cross nearly lead to another own goal as Penney's whipped ball was blazed over the bar by Burton's Ryan Leak.
Edwards, on in place of Barry, nearly made the perfect impression just three minutes into his Town debut. The winger cut inside and curled towards the top corner from 30 yards but Garratt came up with a spectacular, acrobatic stop to push his effort onto the crossbar.
Blues boss Cook was booked with 12 minutes remaining.
The visitors continued to push for the decisive goal, Harper heading over after Fraser's in-swinging free-kick had been flicked on to the back post.
Burton found the deciding goal with four minutes remaining as Akins coolly slotted from the penalty spot after Penney was adjudged to have fouled Powell in the area.
Harper saw an effort from the edge of the box saved in stoppage time as the hosts claimed the three points.
Burton: Garratt, Brayford (C), Powell, Akins, Smith (Bostwick 89), Patrick, O'Connor, Shaughnessy, Taylor (Mancienne 40), Leak, Hamer.
Subs: Balcombe, Borthwick-Jackson, Blake-Tracy, Amadi-Holloway, Williams.
Booked: Taylor, O'Connor, Mancienne.
Town: Hladky, Vincent-Young, Donacien, Woolfenden, Penney, Harper, Evans (C), Fraser, Barry (Edwards 66), Dobra (Bonne 66), Pigott.
Subs: Holy, Ndaba, Clements, El Mizouni, Jackson.