Owls claim spoils in South Yorkshire
Marvin Johnson's early goal condemned Town to a narrow defeat at Sheffield Wednesday.
The winger struck with little over five minutes played to secure all three points for the Owls.
Kieran McKenna made five changes from Tuesday night's victory at AFC Wimbledon. Dominic Thompson, who joined on loan from Brentford until the end of the season on Thursday, started in place of the suspended Kane Vincent-Young.
Idris El Mizouni, Bersant Celina, Conor Chaplin and Macauley Bonne also came back into the starting XI.
The hosts took the lead inside six minutes at Hillsborough. After regaining possession in Town's half, Nathaniel Mendez-Laing's back-post cross was met by a sliding Johnson, who found the bottom corner with an improvised volley.
McKenna's side continued to see plenty of the ball but the next chance went the way of Wednesday, Barry Bannan latching onto a ball over the top of the defence and cutting inside Luke Woolfenden, with George Edmundson clearing the danger before the supporting Josh Windass could pull the trigger.
Town kept looking for a response as, after some one-touch build-up play, Tyreeq Bakinson's dinked ball into the box was just over Macauley Bonne, with a wicked bounce seeing it also evade debutant Thompson. Celina tried his luck with just over half an hour played but, after skipping past a defender, he fired just over the bar from the edge of the area.
Wednesday wasted a huge opportunity to double their advantage just before the break. After a deep cross had fallen into his path, Mendez-Laing skipped inside his marker and drilled an effort from no more than 10 yards wide of the mark.
Christian Walton denied Windass from a tight angle before collecting Sam Hutchinson's header following the resulting corner in the closing moments of the half.
The first chance of the second half went the way of the hosts but Bannan could only head over the bar after Walton had parried Windass' effort into his path.
Town continued to dominate possession but there was little in terms of goalmouth action against a stubborn Owls defence.
Johnson went close to scoring his and Wednesday's second on 67 minutes, the winger dragging an effort wide from the middle of the box following a pull-back from Florian Kemperi.
A stunning diving save from Walton then denied Bannan's well-struck piledriver, which was destined for the top corner before the 'keeper's intervention.
Sone Aluko, introduced alongside James Norwood from the bench, saw a shot blocked after a Wes Burns cross had found him in the middle of the area as the game started to open up.
Norwood headed a Celina corner over the top shortly afterwards before having a powerful effort blocked in the closing stages as the Owls held on to claim the spoils.
Sheff Wed: Peacock-Farrell, Storey, Dean, Hutchinson, Mendez-Laing (Palmer 63'), Dele-Bashiru, Luongo, Bannan (C), Johnson (Hunt 84'), Windass (John-Jules 72'), Kamberi.
Subs: Wildsmith, Byers, Paterson, Sow.
Town: Walton, Donacien, Woolfenden, Edmundson (C), Burns, Bakinson, El Mizouni (Norwood 70'), Celina, Thompson, Chaplin (Aluko 71'), Bonne (Pigott 79').
Subs: Hladky, Burgess, Harper, Edwards.
Attendance: 23,517 (2,818 Town fans)